US3342 has hotkey [Right shift]+[Right Shift] to enable or disable the port switching function.

But if I have other purpose to press the [Right Shift], it will trigger to enable the hotkey.

Is there any other any to disable US3342 hotkey permanently?  

The solution is to connect the keyboard to the second or third USB-A port.

Because the hotkey only works on the first USB port, you could first decide to enable or disable the keyboard.  Then change the keyboard connection to the second or third USB port to avoid the hotkey to be triggered.

US3342 firmware v1.0.074 removes hotkey port switching function and if still need it, please use firmware v1.0.073.